Last update
5/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.2
USERS' SCORE
Good
Based on 13 Reviews
8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Magnesium (from Magnesium Aspartate)
250 mg
60%
Potassium (from Potassium Aspartate)
99 mg
2%
Taurine (Free-Form)
100 mg
†
Top Medical Research Studies
9.5
Niferidil effective for atrial flutter
We evaluated the effectiveness of niferidil, a novel antiarrhythmic agent, in restoring normal heart rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFL). Administered through three intravenous boluses, 134 patients were monitored for their response over 24 hours. We found that 84.6% of patients regained a normal sinus rhythm (SR) after the final dose, with complete success in those with AFL. While a small number of patients experienced minor heart rhythm disturbances, overall, the findings suggest that niferidil is a promising alternative to traditional electrical cardioversion.
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8
Magnesium enhances ibutilide for TAF
We explored how magnesium sulfate influences ibutilide's effectiveness in converting atrial flutter. This randomized, placebo-controlled study included 117 patients with typical (TAF) or atypical atrial flutter (AAF).
Results showed that magnesium significantly enhanced conversion rates in TAF patients—85% with magnesium compared to 59% with placebo. However, for AAF patients, the difference was not significant, with conversion rates at 48% versus 56%. Importantly, magnesium did not impact QT interval durations.
Results showed that magnesium significantly enhanced conversion rates in TAF patients—85% with magnesium compared to 59% with placebo. However, for AAF patients, the difference was not significant, with conversion rates at 48% versus 56%. Importantly, magnesium did not impact QT interval durations.
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8
We explored the effects of nifekalant, a specialized I(Kr) blocker, on typical atrial flutter in 17 patients. After administering nifekalant, we noted a significant increase in the atrial effective refractory period and variability in the AFL-cycle length. This led to the termination of atrial flutter in about 65% of patients, either spontaneously or through stimulated intervention. However, there was no change in AFL-cycle length itself. Overall, nifekalant appears to effectively aid in stopping atrial flutter by modifying electrical conduction patterns in the heart.
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Most Useful Reviews
7.5
Improved heart rhythm
20 people found this helpful
Magnesium and potassium aspartate with taurine is beneficial for cardiovascular health. Initially ordered for my elder relative with heart issues like ischemic heart disease and arrhythmia, I also decided to try it due to my intermittent arrhythmias, particularly after turning 40. After 2 to 3 weeks, I noticed improvements: my blood pressure stabilised and my heartbeats became more regular. The arrhythmia occurrences diminished, and leg cramps disappeared. An unexpected bonus was a sense of calm and reduced swelling. A friend of mine, an athlete, uses it to support heart health and replenish magnesium and potassium lost through sweat, claiming increased activity and endurance with no discomfort after workouts.
Read More
9
Stabilised arrhythmia
8 people found this helpful
After suffering a myocardial infarction in September 2019, I experienced another attack two months later. Following advice from a book by Dr. Mitsuishi and Dr. Fujikawa, I began using this supplement along with others. Since then, my arrhythmia has stabilised, and I have not had any further episodes. Although I cannot pinpoint which supplement brought about the improvement, I feel positive effects from the ones I am taking.
Read More
9
Arrhythmia resolved
I purchased this for my mother, who prefers it over the pharmacy alternatives. She is pleased with the results; her arrhythmia has diminished, and her blood pressure has normalised.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.2
- All Researches
9.5
Niferidil effective for atrial flutter
We evaluated the effectiveness of niferidil, a novel antiarrhythmic agent, in restoring normal heart rhythm in patients with atrial fibrillation (AF) and atrial flutter (AFL). Administered through three intravenous boluses, 134 patients were monitored for their response over 24 hours. We found that 84.6% of patients regained a normal sinus rhythm (SR) after the final dose, with complete success in those with AFL. While a small number of patients experienced minor heart rhythm disturbances, overall, the findings suggest that niferidil is a promising alternative to traditional electrical cardioversion.
Read More
9.5
We examined the potential of niferidile, a new class III antiarrhythmic drug, in treating atrial flutter and fibrillation. This medication works by blocking potassium currents, which helps prolong the heart's recovery time after each beat.
In our analysis, we found that intravenous niferidile successfully converted up to 100% of patients experiencing persistent atrial flutter. While it showed a high effectiveness, there were some risks involved, including a low incidence of serious heart rhythm issues.
Overall, niferidile could serve as a valuable alternative for treating these arrhythmias, particularly when electrical cardioversion isn't suitable.
In our analysis, we found that intravenous niferidile successfully converted up to 100% of patients experiencing persistent atrial flutter. While it showed a high effectiveness, there were some risks involved, including a low incidence of serious heart rhythm issues.
Overall, niferidile could serve as a valuable alternative for treating these arrhythmias, particularly when electrical cardioversion isn't suitable.
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9
We evaluated how magnesium, given intravenously, impacts the effectiveness of ibutilide in converting atrial flutter or fibrillation. In a group of 229 patients, we found that those who received magnesium alongside ibutilide had a significantly higher success rate in chemical conversion—78% more likely than those who did not receive magnesium. A dose of 4 grams seemed to provide the best results. Overall, magnesium appears to enhance the efficacy of ibutilide without major complications.
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9
We explored the effectiveness of ibutilide in converting atrial flutter or fibrillation after amiodarone treatment didn’t work. In this clinical study conducted in an ICU, we monitored 26 patients with persistent arrhythmias. After giving each patient ibutilide, along with magnesium for better results, we found that 81.5% converted to normal sinus rhythm.
However, while many responded well, 11% experienced some nonsustained heart rhythm complications. This indicates ibutilide can be a reliable option when amiodarone fails, with minimal serious side effects.
However, while many responded well, 11% experienced some nonsustained heart rhythm complications. This indicates ibutilide can be a reliable option when amiodarone fails, with minimal serious side effects.
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9
We investigated how NIP-142, a new drug that blocks potassium and other channels, affects atrial flutter and atrial fibrillation (AF). This medication specifically targets potassium currents that are more prevalent in the atria, potentially leading to safer treatment options.
In our studies with canine models, NIP-142 effectively terminated specific types of AF and prolonged the atrial refractory period without impacting conduction times. Despite promising results, more clinical trials are needed to confirm NIP-142's efficacy and safety in humans.
In our studies with canine models, NIP-142 effectively terminated specific types of AF and prolonged the atrial refractory period without impacting conduction times. Despite promising results, more clinical trials are needed to confirm NIP-142's efficacy and safety in humans.
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User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved heart rhythm
20 people found this helpful
Magnesium and potassium aspartate with taurine is beneficial for cardiovascular health. Initially ordered for my elder relative with heart issues like ischemic heart disease and arrhythmia, I also decided to try it due to my intermittent arrhythmias, particularly after turning 40. After 2 to 3 weeks, I noticed improvements: my blood pressure stabilised and my heartbeats became more regular. The arrhythmia occurrences diminished, and leg cramps disappeared. An unexpected bonus was a sense of calm and reduced swelling. A friend of mine, an athlete, uses it to support heart health and replenish magnesium and potassium lost through sweat, claiming increased activity and endurance with no discomfort after workouts.
Read More
9
Stabilised arrhythmia
8 people found this helpful
After suffering a myocardial infarction in September 2019, I experienced another attack two months later. Following advice from a book by Dr. Mitsuishi and Dr. Fujikawa, I began using this supplement along with others. Since then, my arrhythmia has stabilised, and I have not had any further episodes. Although I cannot pinpoint which supplement brought about the improvement, I feel positive effects from the ones I am taking.
Read More
9
Arrhythmia resolved
I purchased this for my mother, who prefers it over the pharmacy alternatives. She is pleased with the results; her arrhythmia has diminished, and her blood pressure has normalised.
Read More
6
Supports heart health
12 people found this helpful
This is a superior version of Russian asparkam. It combines magnesium and potassium asparaginate, known for its ability to enhance the transport of these elements into cells, which is crucial for heart rhythm. Both are vital for our heart's functioning and work closely together for proper absorption. Taurine further enhances their effectiveness, supporting heart and muscle health. Magnesium plays a key role in enzymatic processes and helps regulate blood pressure by participating in cardiac functions. It is also essential for preventing arrhythmia and protecting against cardiovascular issues.
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9
Beneficial for heart
This supplement is excellent for heart issues, particularly arrhythmia. Anyone with a history of heart disease or those who consume coffee may find it beneficial. I wholeheartedly recommend it!
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Frequently Asked Questions
7.5
Improved heart rhythm
20 people found this helpful
Magnesium and potassium aspartate with taurine is beneficial for cardiovascular health. Initially ordered for my elder relative with heart issues like ischemic heart disease and arrhythmia, I also decided to try it due to my intermittent arrhythmias, particularly after turning 40. After 2 to 3 weeks, I noticed improvements: my blood pressure stabilised and my heartbeats became more regular. The arrhythmia occurrences diminished, and leg cramps disappeared. An unexpected bonus was a sense of calm and reduced swelling. A friend of mine, an athlete, uses it to support heart health and replenish magnesium and potassium lost through sweat, claiming increased activity and endurance with no discomfort after workouts.
9
Decreased arrhythmia
The treatment has effectively helped my arrhythmia! After a month, the condition reduced, and I've noticed an improvement in my mood and sleep. The ingredients are well-dosed.
7.5
Reduced heartbeat
Following my cardiologist's advice to take magnesium and potassium supplements for my arrhythmia, I noticed a significant reduction in my heart rate over time. The quality surpasses local brands, and the capsules are conveniently sized.
9
Arrhythmia resolved
I purchased this for my mother, who prefers it over the pharmacy alternatives. She is pleased with the results; her arrhythmia has diminished, and her blood pressure has normalised.
9
Stabilised arrhythmia
8 people found this helpful
After suffering a myocardial infarction in September 2019, I experienced another attack two months later. Following advice from a book by Dr. Mitsuishi and Dr. Fujikawa, I began using this supplement along with others. Since then, my arrhythmia has stabilised, and I have not had any further episodes. Although I cannot pinpoint which supplement brought about the improvement, I feel positive effects from the ones I am taking.
References
- Kukendrarajah K, Ahmad M, Carrington M, Ioannou A, Taylor J, et al. External electrical and pharmacological cardioversion for atrial fibrillation, atrial flutter or atrial tachycardias: a network meta-analysis. Cochrane Database Syst Rev. 2024;6:CD013255. 10.1002/14651858.CD013255.pub2
- Malkoc A, Phan A, Falatoonzadeh P, Mac O, Sherman W, et al. Gender Differences With Ibutilide Effectiveness and Safety in Cardioversion of Atrial Fibrillation. J Surg Res. 2024;296:10. 10.1016/j.jss.2023.12.002
- Malviya A, Kapoor M, Sivam RKN, Khan SA, Pandey R, et al. Ibutilide with magnesium for conversion of atrial fibrillation or flutter in rheumatic heart disease patients: Ibutilide with magnesium for chemical cardioversion of atrial fibrillation or flutter. Indian Heart J. 2020;72:283. 10.1016/j.ihj.2020.07.008
- Wang A. Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillation. Pharm Pract (Granada). 2012;10:65. PubMed
- Patsilinakos S, Christou A, Kafkas N, Nikolaou N, Antonatos D, et al. Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent. Am J Cardiol. 2010;106:673. 10.1016/j.amjcard.2010.04.020
- Coleman CI, Sood N, Chawla D, Talati R, Ghatak A, et al. Intravenous magnesium sulfate enhances the ability of dofetilide to successfully cardiovert atrial fibrillation or flutter: results of the Dofetilide and Intravenous Magnesium Evaluation. Europace. 2009;11:892. 10.1093/europace/eup084
- Steinwender C, Hönig S, Kypta A, Kammler J, Schmitt B, et al. Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter. Int J Cardiol. 2010;141:260. 10.1016/j.ijcard.2008.12.012
- Tercius AJ, Kluger J, Coleman CI, White CM. Intravenous magnesium sulfate enhances the ability of intravenous ibutilide to successfully convert atrial fibrillation or flutter. Pacing Clin Electrophysiol. 2007;30:1331. PubMed
- Bregvadze IN, Maĭkov EB, Bil'dinov OA, Kratskina TL, Klimenko IuL, et al. [The efficacy and safety of nibentan for pharmacological cardioversion in patients with persistent atrial fibrillation and flutter: the role of dose limitation and magnesium sulfate administration]. Kardiologiia. 2007;47:48. PubMed
- Sedrakyan A, Treasure T, Browne J, Krumholz H, Sharpin C, et al. Pharmacologic prophylaxis for postoperative atrial tachyarrhythmia in general thoracic surgery: evidence from randomized clinical trials. J Thorac Cardiovasc Surg. 2005;129:997. PubMed
- Kalus JS, Spencer AP, Tsikouris JP, Chung JO, Kenyon KW, et al. Impact of prophylactic i.v. magnesium on the efficacy of ibutilide for conversion of atrial fibrillation or flutter. Am J Health Syst Pharm. 2003;60:2308. PubMed
- Caron MF, Kluger J, Tsikouris JP, Ritvo A, Kalus JS, et al. Effects of intravenous magnesium sulfate on the QT interval in patients receiving ibutilide. Pharmacotherapy. 2003;23:296. PubMed
- Hennersdorf MG, Perings SM, Zühlke C, Heidland UE, Perings C, et al. Conversion of recent-onset atrial fibrillation or flutter with ibutilide after amiodarone has failed. Intensive Care Med. 2002;28:925. PubMed
- Jensen BM, Alstrup P, Klitgård NA. Magnesium substitution and postoperative arrhythmias in patients undergoing coronary artery bypass grafting. Scand Cardiovasc J. 1997;31:265. PubMed
- Joshi PP, Deshmukh PK, Salkar RG. Efficacy of intravenous magnesium sulphate in supraventricular tachyarrhythmias. J Assoc Physicians India. 1995;43:529. PubMed
- Casthely PA, Yoganathan T, Komer C, Kelly M. Magnesium and arrhythmias after coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 1994;8:188. PubMed
- Li S, Zhang Z, Ding Y, Yu T, Qin Z, et al. Dissecting the associations of KCNH2 genetic polymorphisms with various types of cardiac arrhythmias. Gene. 2024;899:148132. 10.1016/j.gene.2024.148132
- Yahya AMB, Ahmed N, Qayyum H. An Interesting Case of Weakness and Atrial Tachycardia in the Emergency Department: Thinking Beyond Hearts and Minds. Cureus. 2023;15:e38002. 10.7759/cureus.38002
- Cacioppo F, Reisenbauer D, Herkner H, Oppenauer J, Schuetz N, et al. Association of Intravenous Potassium and Magnesium Administration With Spontaneous Conversion of Atrial Fibrillation and Atrial Flutter in the Emergency Department. JAMA Netw Open. 2022;5:e2237234. 10.1001/jamanetworkopen.2022.37234
- Harkness W, Watts P, Kopstein M, Dziadkowiec O, Hicks G, et al. Correcting Hypokalemia in Hospitalized Patients Does Not Decrease Risk of Cardiac Arrhythmias. Adv Med. 2019;2019:4919707. 10.1155/2019/4919707
- Maykov EB, Yuricheva YA, Mironov NY, Sokolov SF, Golitsyn SP, et al. [Refralon (niferidil) is a new class III antiarrhythmic agent for pharmacological cardioversion for persistent atrial fibrillation and atrial flutter]. Ter Arkh. 2015;87:38. 10.17116/terarkh201587138-48
- Maĭkov EB, Iuricheva IuA, Mironov NIu, Sokolov SF, Golitsyn SP, et al. [Novel class III antiarrhythmic agent niferidile: review of experimental and clinical studies]. Kardiologiia. 2014;54:4. PubMed
- Banchs JE, Baquero GA, Nickolaus MJ, Wolbrette DL, Kelleman JJ, et al. Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease. Congenit Heart Dis. 2014;9:221. 10.1111/chd.12129
- Yamabe H, Tanaka Y, Morihisa K, Uemura T, Koyama J, et al. Electrophysiologic mechanism of typical atrial flutter termination by nifekalant: effect of a pure IKr -selective blocking agent. Pacing Clin Electrophysiol. 2013;36:1123. 10.1111/pace.12147
- Serafimovski N, Burke P, Khawaja O, Sekulic M, Machado C. Usefulness of dofetilide for the prevention of atrial tachyarrhythmias (atrial fibrillation or flutter) after coronary artery bypass grafting. Am J Cardiol. 2008;101:1574. 10.1016/j.amjcard.2008.01.044
- Tanaka H, Hashimoto N. A multiple ion channel blocker, NIP-142, for the treatment of atrial fibrillation. Cardiovasc Drug Rev. 2007;25:342. PubMed
- Vernakalant: RSD 1235, RSD-1235, RSD1235. Drugs R D. 2007;8:259. PubMed
